Double blind randomized phase II study with radiation+ 5-fluorouracil±celecoxib for resectable rectal cancer
A Debucquoy, S Roels, L Goethals, L Libbrecht… - Radiotherapy and …, 2009 - Elsevier
PURPOSE: To assess the feasibility and efficacy of the COX-2 inhibitor celecoxib in
conjunction with preoperative chemoradiation for patients with locally advanced rectal
cancer in a double blind randomized phase II study. MATERIALS AND METHODS: Thirty-
five patients of the initially planned 80 patients with locally advanced rectal cancer were
treated with preoperative radiation (45Gy; 1.8 Gy/fraction, 5days/week) combined with 5-
fluorouracil (continuous infusion, 225mg/m2/day) and celecoxib (2× 400mg/day) or placebo …
conjunction with preoperative chemoradiation for patients with locally advanced rectal
cancer in a double blind randomized phase II study. MATERIALS AND METHODS: Thirty-
five patients of the initially planned 80 patients with locally advanced rectal cancer were
treated with preoperative radiation (45Gy; 1.8 Gy/fraction, 5days/week) combined with 5-
fluorouracil (continuous infusion, 225mg/m2/day) and celecoxib (2× 400mg/day) or placebo …
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