Bulk rock lithium and oxygen isotope compositions from ODP Site 1256 were analyzed to investigate the seawater circulation in the upper oceanic crust formed at the East Pacific Rise (EPR). The upper extrusive basalts have δ¹⁸O values from +6.1‰ to +9.2‰, reflecting alteration of oceanic crust by seawater at low temperatures (<200–250°C). Bulk rocks from the sheeted dike complex and plutonic section have overall lower δ¹⁸O values (+3.0‰–+5.5‰). In the sheeted dike complex bulk rock δ¹⁸O values gradually decrease with depth, and then increase toward the fresh MORB δ¹⁸O value after reaching a minimum of +3.0‰ at ∼1350 m below seafloor (mbsf). The entire sampled crust is dominated by rocks with low lithium contents relative to fresh MORBs except for a few localized Li enrichment. The upper volcanic zone is characterized by a spread of δ⁷Li from low to high values relative to average unaltered MORB values (δ⁷Li = +3.4 ± 1.4‰). The presence of rocks with low δ⁷Li values in the upper crust most likely indicates zones of upwelling of relatively hot (∼200–250°C) hydrothermal fluids. In the sheeted dike complex, bulk rock δ⁷Li values show wide range of variation, but exhibit a general trend from enriched to depleted values at ∼1280 mbsf and then return to that for fresh MORB within the upper tens of meters of the plutonic section at the bottom of the after reaching a minimum at ∼1350 mbsf (δ⁷Li = −1.6‰). The downhole pattern of δ⁷Li principally reflects variations in water‐rock ratio (w/r) together with a downhole increase of temperature. Seawater flow in the upper volcanic zone is likely to be channeled with generally small but variable w/r ratios. The w/r ratios increase rapidly with depth in the lower volcanic section into the sheeted dike complex indicating water dominated pervasive hydrothermal flow due to intensive upwelling of hydrothermal fluids.