Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Pretomanid is a nitroimidazole antimicrobial active against drug-resistant Mycobacterium
tuberculosis and approved in combination with bedaquiline and linezolid (BPaL) to treat
multidrug-resistant (MDR) pulmonary tuberculosis (TB). However, the penetration of these
antibiotics into the central nervous system (CNS), and the efficacy of the BPaL regimen for
TB meningitis, are not well established. Importantly, there is a lack of efficacious treatments
for TB meningitis due to MDR strains, resulting in high mortality. We have developed new …
tuberculosis and approved in combination with bedaquiline and linezolid (BPaL) to treat
multidrug-resistant (MDR) pulmonary tuberculosis (TB). However, the penetration of these
antibiotics into the central nervous system (CNS), and the efficacy of the BPaL regimen for
TB meningitis, are not well established. Importantly, there is a lack of efficacious treatments
for TB meningitis due to MDR strains, resulting in high mortality. We have developed new …
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