Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity
TMEM16F is activated by elevated intracellular Ca2+, and functions as a small-conductance
ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B
calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-,
anion-, or non-selective ion channel, without a definite conclusion. Starting with the Q559K
mutant that shows no current rundown and less outward rectification in excised patch, we
found that the channel shifted its ion selectivity in response to the change of intracellular …
ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B
calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-,
anion-, or non-selective ion channel, without a definite conclusion. Starting with the Q559K
mutant that shows no current rundown and less outward rectification in excised patch, we
found that the channel shifted its ion selectivity in response to the change of intracellular …
[PDF][PDF] Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion
W Ye, TW Han, M He - 2019 - scholar.archive.org
TMEM16F is activated by elevated intracellular Ca2+, and functions as a smallconductance
ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B
calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-,
anion-, or non-selective ion channel, without a definite conclusion. Starting with the Q559K
mutant that shows no current rundown and less outward rectification in excised patch, we
found that the channel shifted its ion selectivity in response to the change of intracellular …
ion channel and as a phospholipid scramblase. In contrast to its paralogs, the TMEM16A/B
calcium-activated chloride channels, mouse TMEM16F has been reported as a cation-,
anion-, or non-selective ion channel, without a definite conclusion. Starting with the Q559K
mutant that shows no current rundown and less outward rectification in excised patch, we
found that the channel shifted its ion selectivity in response to the change of intracellular …
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