Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells
A Bort, BG Sánchez, I de Miguel… - Molecular biology …, 2020 - Springer
According to the stem cell theory for cancer, hepatocellular carcinomas are sustained by a
group of cancer stem cells (CSCs) which are responsible for resistance to chemotherapy. In
the present study we aimed to examine lipid metabolism in cancer stem cells induced by
long-term treatment with sorafenib and its relationship with acquisition of a CSC-like
phenotype. Two cell lines (HepG2SF1 and Huh7SF1) were generated by incubation with a
step-wise increase of sorafenib concentrations for 10 months. These cell lines displayed …
group of cancer stem cells (CSCs) which are responsible for resistance to chemotherapy. In
the present study we aimed to examine lipid metabolism in cancer stem cells induced by
long-term treatment with sorafenib and its relationship with acquisition of a CSC-like
phenotype. Two cell lines (HepG2SF1 and Huh7SF1) were generated by incubation with a
step-wise increase of sorafenib concentrations for 10 months. These cell lines displayed …
Dysregulated lipid metabolism in hepatocellular carcinoma cancer stem cells
AC Bort Bueno, B Sánchez Gómez, I Miguel García… - 2020 - ebuah.uah.es
According to the stem cell theory for cancer, hepatocellular carcinomas are sustained by a
group of cancer stem cells (CSCs) which are responsible for resistance to chemotherapy. In
the present study we aimed to examine lipid metabolism in cancer stem cells induced by
long-term treatment with sorafenib and its relationship with acquisition of a CSC-like
phenotype. Two cell lines (HepG2SF1 and Huh7SF1) were generated by incubation with a
step-wise increase of sorafenib concentrations for 10 months. These cell lines displayed …
group of cancer stem cells (CSCs) which are responsible for resistance to chemotherapy. In
the present study we aimed to examine lipid metabolism in cancer stem cells induced by
long-term treatment with sorafenib and its relationship with acquisition of a CSC-like
phenotype. Two cell lines (HepG2SF1 and Huh7SF1) were generated by incubation with a
step-wise increase of sorafenib concentrations for 10 months. These cell lines displayed …
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