Abstract Background Early clearance of Mycobacterium tuberculosis is the eradication of
infection before an adaptive immune response develops. We aimed to identify host factors
associated with early clearance. Methods Indonesian household contacts patients with
smear-positive tuberculosis (TB) had an interferon-γ release assay (IGRA) at baseline and
14 weeks later. Early clearance was defined as a persistently negative IGRA. Contact
characteristics, exposure, and disease phenotype were assessed for association with a …

Introduction: Early clearance of M. tuberculosis is the eradication of infection before an
adaptive immune response develops. We studied highly exposed Tuberculosis (TB) case
contacts to identify host factors associated with early clearance. Methods: Indonesian
household contacts of sputum smear positive TB cases were recruited. An Interferon Gamma
Release Assay (IGRA) was performed at baseline and 14 weeks. Early clearance was
defined as a persistently negative IGRA. Contacts were characterised with respect to …