Microstrip Moisture Sensor is designed for detection of dissolved salt and sugar in liquid medium. Sensor size is, determined by CST software analysis, 50 mm × 50 mm fabricated on FR 4 substrate which is low cost and easily available. Sensor is designed for four frequency, 3.4 GHz, 5.8 GHz, 6.2 GHz and 8.9 GHz, selected between the range of 3 GHz to 9 GHz. These four frequency is selected because of having lowest reflection coefficient between 3 to 9 GHz. To check the accuracy of sensor, whether it is eligible to work, gain and efficiency is determined for ideal (simulated, calculated from CST software) and actual (measured, determined by VNA). Simulated gain and efficiency are found to be approximately equal to measured gain and efficiency. Hence, it can be conclude that sensor is applicable for detection of salt and sugar. Now, sensor is tested for salt and sugar solution, each having four samples. This microstrip moisture sensor is work on the principle of direct transmission method which is based upon the amount of absorption of radiation in the solution. Amount of absorption of radiation by the solution is given by VNA, termed as reflection coefficient. Higher the salt or sugar, absorption will be more and results in increase of reflection coefficient. It means design sensor is accurate. Hence, it can be say that sensor is now available for detection of salt and sugar, having applications in various field such as food industry, construction industry for water supply engineering.