Early evaluation of corneal collagen crosslinking in ex-vivo human corneas using two-photon imaging
The clinical outcome of corneal collagen crosslinking (CXL) is typically evaluated several
weeks after treatment. An earlier assessment of its outcome could lead to an optimization of
the treatment, including an immediate re-intervention in case of failure, thereby, avoiding
additional discomfort and pain to the patient. In this study, we propose two-photon imaging
(TPI) as an earlier evaluation method. CXL was performed in human corneas by application
of riboflavin followed by UVA irradiation. Autofluorescence (AF) intensity and lifetime images …
weeks after treatment. An earlier assessment of its outcome could lead to an optimization of
the treatment, including an immediate re-intervention in case of failure, thereby, avoiding
additional discomfort and pain to the patient. In this study, we propose two-photon imaging
(TPI) as an earlier evaluation method. CXL was performed in human corneas by application
of riboflavin followed by UVA irradiation. Autofluorescence (AF) intensity and lifetime images …
Early evaluation of corneal collagen crosslinking in ex-vivo human corneas using two-photon imaging
AM Goncalves Batista, HG Breunig, T Hager… - 2019 - publikationen.sulb.uni-saarland.de
The clinical outcome of corneal collagen crosslinking (CXL) is typically evaluated several
weeks after treatment. An earlier assessment of its outcome could lead to an optimization of
the treatment, including an immediate re-intervention in case of failure, thereby, avoiding
additional discomfort and pain to the patient. In this study, we propose two-photon imaging
(TPI) as an earlier evaluation method. CXL was performed in human corneas by application
of riboflavin followed by UVA irradiation. Autofluorescence (AF) intensity and lifetime images …
weeks after treatment. An earlier assessment of its outcome could lead to an optimization of
the treatment, including an immediate re-intervention in case of failure, thereby, avoiding
additional discomfort and pain to the patient. In this study, we propose two-photon imaging
(TPI) as an earlier evaluation method. CXL was performed in human corneas by application
of riboflavin followed by UVA irradiation. Autofluorescence (AF) intensity and lifetime images …
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