Thirty mice were used in this study in the ages of (4-8 weeks) and body weight of (25+ 2 g) for the investigation of the histological effects of Anastatica hierochuntica aqueous extract in mice kidneys. Mice were divided into three groups where the first group was the control group that received daily orally administration of (1ml) of distilled water for two months. The second group were orally administered with a daily dose of (0.1 g/ml) of the plant aqueous extract for one month. While, the third group had received the same dose of the second group but for two months. Animals were slayed at the end of the first and the second month and kidneys were autopsied and their histology section slides were examined by light microscope and photographed. Then, images were assessed histopathologically and comparisons were made between the treated groups of mice with the control group. Results showed that, the administration of daily oral doses of (0.1 g/ml) of Anastatica hierochuntica aqueous extract for one week did not bring any change to the macroscopic appearance nor to the histology sections of the kidney tissues of the treated animal. whereas, the treatment with daily oral doses of (0.1 g/ml) of the aqueous extract for one month had significant effects (P≤ 0.05) on the mice kidney tissues that included lymphocyte infiltration, necrosis, degeneration and swelling of the glomeruli where the kidneys appeared congested upon macroscopic examination. While, the continual treatment of the animals with the same doses of the plant extract for a second month resulted in an increased damage to the kidney tissues with a complete loss in kidney tissue architecture.