The present research was undertaken to study the effects of oral intake of Pineapple (Ananas comosus L.) Leaves Extract (PLE) at three dosage (250, 500 and 750 mg/kg b. wt.) on hypercholesterolemic rats after 4 weeks of treatment on body weight gain%(BWG%), feed efficiency ratio (FER) and relative weight of liver. Histopathological examination of liver was also studied. Thirty male Wister Albino rats were distributed into five equal groups (6 rats each) as follows: group1: negative control group, group 2: positive control (hypercholesterolemia rats) group, groups 3, 4 and 5 fed. on high cholesterol and high fat diet (HCFD) and treated with orally doses of PLE of 250, 500 and 750mg/kg b. wt., respectively. The results showed that, the total content of phenolic compound of pineapple leaves extract was 22.28 mg/100 ml. oral intake of Pineapple (Ananas comosus L.) leaves extracts (PLE) at three dosage (250, 500 and 750mg/kg) for four weeks to hypercholesterolemia rats reduces body weight gain and feed efficiency ratio. On the other hand, the decreased of liver weight compared to hypercholesterolemia male rats (positive control group) by 27.77%, 34. 82% and 64.63% were observed at the three dosage (250, 500 or 750mg/kg) respectively. Histopathological examination of liver sections of rats of PLE-treated groups showed amelioration of histological changes caused by high level of cholesterol in the positive control group.