This study aims to analyze the effect of profitability and leverage on dividend policy with the investment opportunity set (IOS) as a moderating variable in manufacturing companies listed on the Bursa Efek Indonesia (BEI) from 2014 to 2018. The population in this study amounted to 158 manufacturing companies, 20 manufacturing companies were obtained by using purposive sampling technique, this type of research is associative causal. The technique used in this research is descriptive statistical analysis technique using the SPSS 24 program. The results of this study indicate that profitability has a significant positive effect on dividend policy. Leverage has no effect on dividend policy. The investment opportunity set (IOS) is unable to moderate the relationship between profitability and dividend policy. The investment opportunity set (IOS) is also unable to moderate the relationship between leverage and dividend policy.