Importance Patients with soft tissue sarcoma are at risk for local recurrence and distant
metastases despite optimal local treatment. Preoperative anthracycline plus ifosfamide
chemotherapy improves outcome in common histological subtypes. Objective To analyze
whether the previously reported improvement in local progression-free survival by adding
regional hyperthermia to neoadjuvant chemotherapy translates into improved survival.
Design, Setting, and Participants Open-label, phase 3 randomized clinical trial to evaluate …