Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial
JF Rossignol, M Abu-Zekry, A Hussein, MG Santoro - The Lancet, 2006 - thelancet.com
Background Rotavirus is a leading cause of morbidity and mortality in children younger than
5 years, but there is no effective treatment. We assessed the activity of nitazoxanide, a broad-
spectrum anti-infective drug, against rotavirus in cell culture and in a clinical trial in
paediatric patients hospitalised with severe rotavirus diarrhoea. Methods We did a
randomised double-blind placebo-controlled trial in 50 children admitted to the Cairo
University Children's Hospital between June 15 and Aug 23, 2005, with severe rotavirus …
5 years, but there is no effective treatment. We assessed the activity of nitazoxanide, a broad-
spectrum anti-infective drug, against rotavirus in cell culture and in a clinical trial in
paediatric patients hospitalised with severe rotavirus diarrhoea. Methods We did a
randomised double-blind placebo-controlled trial in 50 children admitted to the Cairo
University Children's Hospital between June 15 and Aug 23, 2005, with severe rotavirus …