The UK Turner syndrome (TS) study examined the effect on final height of oxandrolone 0.05
mg/kg/day (maximum dose 2.5 mg) versus placebo from 9 years of age; and delaying
ethinylestradiol induction of puberty by 2 years from 12 (E12) to 14 (E14) years in growth
hormone-treated girls with TS. The study ran from 1999 to 2013. By 2011, eighty-two of 92
participants had reached final height and an interim analysis using the Super-Imposition by
Translation And Rotation model showed significant increases in final height with both …

Objective To examine the effect of oxandrolone and the timing of pubertal induction on final
height in girls with Turner's syndrome receiving a standard dose of growth hormone. Design
Randomised, double blind, placebo controlled trial. Setting 36 paediatric endocrinology
departments in UK hospitals. Participants Girls with Turner's syndrome aged 7-13 years at
recruitment, receiving recombinant growth hormone therapy (10 mg/m 2/week). Interventions
Participants were randomised to oxandrolone (0.05 mg/kg/day, maximum 2.5 mg/day) or …