Effect of prophylactic phenobarbital on seizures, encephalopathy and mortality in neonates with perinatal asphyxia

S Velaphi, M Mokhachane, R Mphahlele… - South African Journal of …, 2013 - ajol.info
S Velaphi, M Mokhachane, R Mphahlele, E Beckh-Arnold
South African Journal of Child Health, 2013ajol.info
Background. Seizures after an asphyxial insult may result in brain damage in neonates.
Prophylactic phenobarbital may reduce seizures. Objective. To determine the e€ ect of
prophylactic phenobarbital on seizures, death and neurological outcome at hospital
discharge. Methods. Neonates with base de. cit> 16 mmol/l and Apgar score at 5 minutes< 7
or requiring resuscitation for> 5 minutes at the time of
Abstract
Background. Seizures after an asphyxial insult may result in brain damage in neonates. Prophylactic phenobarbital may reduce seizures.
Objective. To determine the e€ ect of prophylactic phenobarbital on seizures, death and neurological outcome at hospital discharge.
Methods. Neonates with base de. cit> 16 mmol/l and Apgar score at 5 minutes< 7 or requiring resuscitation for> 5 minutes at the time of
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