properties of plasticized and unplasticized hydroxypropyl methylcellulose films (HPMC) filled
with two types of titanium dioxide (one of which is surface-treated) and two types of talc
(different specific surface areas), respectively, have been examined. The plasticizer was
believed to interact more strongly than the film-former (HPMC) with the fillers, a behaviour
with dramatic consequences on the tensile strength, Young's modulus and elongation of the …
The effect of interactions between film formers and dispersed solids on the permeation
properties of some tablet film coats have been investigated. Two polymer systems were
employed: hydroxypropyl methylcellulose (HMPC) and HPMC plasticized with polyethylene
glycol (PEG) 400. Two types of titanium dioxide (one of which was surface-treated to
increase its hydrophobocity) and two types of talc (differing in particle size) were the solids.
The diffusion, solubility and permeability coefficients of the films were obtained from sorption …