[HTML][HTML] Effect of the fourth nucleotide at the 3′ end of neuraminidase and matrix viral genomic RNA on the pathogenicity of influenza virus A/PR/8/34
CY Lee, HJ Kwon, TT Nguyen, I Kim… - Journal of Veterinary …, 2017 - ncbi.nlm.nih.gov
Twelve nucleotides located at the 3′ end of viral genomic RNA (vRNA) are conserved
among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid
reverse genetics vector system introduced mutations at position 4, C nucleotide (C4) to U
nucleotide (U4), of the 3′ ends of neuraminidase (NA) and matrix (M) vRNAs of wild-type
A/PR/8/34 (PR8). This resulted in a constellation of C4 and U4 vRNAs coding for low
(polymerases) and relatively high (all others) copy number proteins, respectively. U4 has …
among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid
reverse genetics vector system introduced mutations at position 4, C nucleotide (C4) to U
nucleotide (U4), of the 3′ ends of neuraminidase (NA) and matrix (M) vRNAs of wild-type
A/PR/8/34 (PR8). This resulted in a constellation of C4 and U4 vRNAs coding for low
(polymerases) and relatively high (all others) copy number proteins, respectively. U4 has …
Effect of the fourth nucleotide at the 3′ end of neuraminidase and matrix viral genomic RNA on the pathogenicity of influenza virus A/PR/8/34.
LCY Lee ChungYoung, KHJ Kwon HyukJoon… - 2017 - cabidigitallibrary.org
Twelve nucleotides located at the 3′ end of viral genomic RNA (vRNA) are conserved
among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid
reverse genetics vector system introduced mutations at position 4, C nucleotide (C4) to U
nucleotide (U4), of the 3′ ends of neuraminidase (NA) and matrix (M) vRNAs of wild-type
A/PR/8/34 (PR8). This resulted in a constellation of C4 and U4 vRNAs coding for low
(polymerases) and relatively high (all others) copy number proteins, respectively. U4 has …
among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid
reverse genetics vector system introduced mutations at position 4, C nucleotide (C4) to U
nucleotide (U4), of the 3′ ends of neuraminidase (NA) and matrix (M) vRNAs of wild-type
A/PR/8/34 (PR8). This resulted in a constellation of C4 and U4 vRNAs coding for low
(polymerases) and relatively high (all others) copy number proteins, respectively. U4 has …
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