Effect of tumour necrosis factor-alpha and interleukin-6 promoter polymorphisms on course of Crimean-Congo hemorrhagic fever in Turkish patients
Objective: In this case-control study, we investigated whether IL-6 (-174G/C) and TNF-α (-
308G/A) gene polymorphisms affect the clinical course and outcome of CCHF. Methods:
Total 150 patients with CCHF and 170 controls were examined in this study. Genotyping of
these polymorphisms were performed by PCR-RFLP methods. Results: We found no
statistically significant differences in genotype and allele frequencies of these
polymorphisms between patients and controls [(χ2= 1.31, p= 0.51 for TNF-α) and (χ2= 2.61 …
308G/A) gene polymorphisms affect the clinical course and outcome of CCHF. Methods:
Total 150 patients with CCHF and 170 controls were examined in this study. Genotyping of
these polymorphisms were performed by PCR-RFLP methods. Results: We found no
statistically significant differences in genotype and allele frequencies of these
polymorphisms between patients and controls [(χ2= 1.31, p= 0.51 for TNF-α) and (χ2= 2.61 …
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