Effectiveness of aprotinin in orthotopic liver transplantation

M Suárez, B Sangro, JI Herrero… - … in thrombosis and …, 1993 - thieme-connect.com
M Suárez, B Sangro, JI Herrero, A Picardi, JA Páramo, J Quiroga, F Pardo, A Javier…
Seminars in thrombosis and hemostasis, 1993thieme-connect.com
Hyperfibrinolysis or disseminated intravascular coagulation (DIC) seem to play an important
role in intraoperative bleeding. The most striking hemostatic abnormalities during OLT occur
late in the anhepatic phase and immediately after graft revascularization. 3" 6 At present,
there is no standard treatment for these disorders. 7 Epsilon-aminocaproic acid has been
administered without reduction in blood requirements, while antifibrinolytic agents have
been used with some degree of success. 8 Aprotinin is a naturally occurring polypeptide that …
Hyperfibrinolysis or disseminated intravascular coagulation (DIC) seem to play an important role in intraoperative bleeding. The most striking hemostatic abnormalities during OLT occur late in the anhepatic phase and immediately after graft revascularization. 3" 6 At present, there is no standard treatment for these disorders. 7 Epsilon-aminocaproic acid has been administered without reduction in blood requirements, while antifibrinolytic agents have been used with some degree of success. 8 Aprotinin is a naturally occurring polypeptide that acts as an inhibitor of human plasmin, trypsin, and kallikrein and can inhibit the development of fibrinolysis. 9 Aprotinin has also proved to be useful in reducing operative bleeding in cardiac surgery, 10 and the initial results in OLT are promising. 3, 11, 12 The aim of this preliminary study was to evaluate the effectiveness of aprotinin against blood loss during OLT.
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