[HTML][HTML] Effects of aerobic exercise on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue

AC Rodrigues, TF Leal, AJLD Costa, F de Jesus Silva… - Life sciences, 2019 - Elsevier
AC Rodrigues, TF Leal, AJLD Costa, F de Jesus Silva, LL Soares, PC Brum
Life sciences, 2019Elsevier
Aim Investigate the effects of moderate continuous aerobic exercise (MCAE) on the
inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β 1-
AR−/− mice adipose tissue. Main methods Four-to five-month-old male wild type (WT) and β
1-AR−/− mice were divided into groups: WT control (WTc) and trained (WTt); and β 1-AR−/−
control (β 1-AR−/− c) and trained (β 1-AR−/− t). Animals from trained groups were submitted
to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 …
Aim
Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue.
Main methods
Four- to five-month-old male wild type (WT) and β1-AR−/− mice were divided into groups: WT control (WTc) and trained (WTt); and β1-AR−/− control (β1-AR−/−c) and trained (β1-AR−/−t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks. After euthanasia, white epididymal (eWAT) and inguinal (iWAT) and brown (BAT) adipose tissues were dissected and used to determine: adiposity index; adipocyte histomorphometry; cytokine concentration; and gene expression. The content of fat, protein and water of the empty carcass was determined.
Key findings
MCAE reduced body weight, fat mass as well as iWAT and BAT adipocyte area in β1-AR−/− animals. Aerobic exercise also diminished the concentrations of pro-inflammatory (IL-12p70, TNF-α, IL-6) and anti-inflammatory (IL-10) cytokines in adipose tissue (iWAT, eWAT or BAT) of β1-AR−/− mice. However, MCAE had no effect on the expression lipolytic and thermogenic genes in β1-AR−/− mice adipose tissue.
Significance
Alongside reductions in body weight, fat mass and adipocyte area eight weeks of MCAE improves the profile of inflammatory cytokines in β1-AR−/− mice adipose tissue, despite no change in Lipolytic and thermogenic gene expression.
Elsevier
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