Effects of anti-phospholipid antibodies on a human trophoblast cell line (HTR-8/SVneo)
M Jovanović, M Božić, T Kovačević, L Radojčić… - Acta histochemica, 2010 - Elsevier
Antibodies to phospholipids (aPL) have been shown to adversely affect trophoblast invasion
in vivo and in vitro. HTR-8/SVneo cells derived from first trimester of pregnancy extravillous
trophoblast were studied. Matrigel invasion assay, cytochemistry and cell-based enzyme-
linked immunosorbant assay (ELISA) with aPL or normal IgG was used. Our data show that
aPL at 100μg/ml decrease invasiveness of HTR-8/SVneo cells to 60% of control (p< 0.01),
and this was also shown for primary cytotrophoblast (to 15.5% of control, p< 0.001). aPL …
in vivo and in vitro. HTR-8/SVneo cells derived from first trimester of pregnancy extravillous
trophoblast were studied. Matrigel invasion assay, cytochemistry and cell-based enzyme-
linked immunosorbant assay (ELISA) with aPL or normal IgG was used. Our data show that
aPL at 100μg/ml decrease invasiveness of HTR-8/SVneo cells to 60% of control (p< 0.01),
and this was also shown for primary cytotrophoblast (to 15.5% of control, p< 0.001). aPL …
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