Effects of genipin crosslinking on mechanical cell-matrix interaction in 3D engineered tendon constructs
A Giannopoulos, RB Svensson, CYC Yeung… - Journal of the …, 2021 - Elsevier
It is well known that cells can generate endogenous forces onto the extracellular matrix, but
to what extent the mechanical properties of the matrix influences these endogenous cellular
forces remains unclear. We therefore sought to quantify the influence of matrix rigidity on cell-
matrix interactions by inducing cross-links using increasing concentrations of genipin (0.01–
1 mM) or by blocking cross-link formation using beta-aminopropionitrile (BAPN) in
engineered human tendon tissue constructs. The cell-matrix mechanics of the tendon …
to what extent the mechanical properties of the matrix influences these endogenous cellular
forces remains unclear. We therefore sought to quantify the influence of matrix rigidity on cell-
matrix interactions by inducing cross-links using increasing concentrations of genipin (0.01–
1 mM) or by blocking cross-link formation using beta-aminopropionitrile (BAPN) in
engineered human tendon tissue constructs. The cell-matrix mechanics of the tendon …
Effects of genipin crosslinking on mechanical cell-matrix interaction in 3D engineered tendon constructs
CYC Yeung - Journal of the Mechanical Behavior of Biomedical …, 2021 - research.regionh.dk
It is well known that cells can generate endogenous forces onto the extracellular matrix, but
to what extent the mechanical properties of the matrix influences these endogenous cellular
forces remains unclear. We therefore sought to quantify the influence of matrix rigidity on cell-
matrix interactions by inducing cross-links using increasing concentrations of genipin (0.01–
1 mM) or by blocking cross-link formation using beta-aminopropionitrile (BAPN) in
engineered human tendon tissue constructs. The cell-matrix mechanics of the tendon …
to what extent the mechanical properties of the matrix influences these endogenous cellular
forces remains unclear. We therefore sought to quantify the influence of matrix rigidity on cell-
matrix interactions by inducing cross-links using increasing concentrations of genipin (0.01–
1 mM) or by blocking cross-link formation using beta-aminopropionitrile (BAPN) in
engineered human tendon tissue constructs. The cell-matrix mechanics of the tendon …
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