Effects of ketamine on cardiovascular and respiratory responses to traumatic hemorrhage in rats
C Hinojosa-Laborde, M Calderon, S Crimmins… - The Journal of …, 2018 - jpain.org
TV at 10 min (2.4±. 4 vs 1.6±. 1 ml; P=. 01) and 45 min (2.3±. 3 vs 1.6±. 1 ml; P=. 03) post
injection was greater in S vs K rats. RR at 10 min post injection was less in S vs K rats
(134±12 vs 187±11 breaths/min; P=. 04). Differences were transient and were not observed
after these time points. These results show that at the time administered, and at the
analgesic dose given, ketamine had minimal effects on cardiovascular and respiratory
function for up to~ 3.5 hours after injection in an animal model of trauma and hemorrhage …
injection was greater in S vs K rats. RR at 10 min post injection was less in S vs K rats
(134±12 vs 187±11 breaths/min; P=. 04). Differences were transient and were not observed
after these time points. These results show that at the time administered, and at the
analgesic dose given, ketamine had minimal effects on cardiovascular and respiratory
function for up to~ 3.5 hours after injection in an animal model of trauma and hemorrhage …
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