BACKGROUND: Many chronic liver diseases lead to progressive hepatic fibrosis, a
condition that can ultimately result in loss of organ function and severe portal hypertension
necessitating hepatic transplantation. Within the last few decades, studies have been
conducted to demonstrate the possibility of drug modulation of hepatic fibrogenesis.
Regarding biliary obstruction, it has been suggested that administration of corticosteroids
could promote better late outcomes for children with biliary atresia submitted to Kasai's …

OBJECTIVE: During the neonatal and infancy periods, some chronic liver diseases may lead
to progressive hepatic fibrosis, which is a condition that can ultimately result in the loss of
organ function and severe portal hypertension necessitating hepatic transplantation. In a
previous report, pharmacological interventions were demonstrated to modulate hepatic
fibrosis induced by bile duct ligation in young rats. The administration of pentoxifylline or
prednisolone, or the combination of both, resulted in reduced fibrogenesis in portal spaces …