Effects of trehalose polycation end-group functionalization on plasmid DNA uptake and transfection
In this study, we have synthesized six analogs of a trehalose-pentaethylenehexamine
glycopolymer (Tr4) that contain (1A) adamantane,(1B) carboxy,(1C) alkynyl-
oligoethyleneamine,(1D) azido trehalose,(1E) octyl, or (1F) oligoethyleneamine end groups
and evaluated the effects of polymer end group chemistry on the ability of these systems to
bind, compact, and deliver pDNA to cultured HeLa cells. The polymers were synthesized in
one-pot azide–alkyne cycloaddition reactions with an adaptation of the Carothers equation …
glycopolymer (Tr4) that contain (1A) adamantane,(1B) carboxy,(1C) alkynyl-
oligoethyleneamine,(1D) azido trehalose,(1E) octyl, or (1F) oligoethyleneamine end groups
and evaluated the effects of polymer end group chemistry on the ability of these systems to
bind, compact, and deliver pDNA to cultured HeLa cells. The polymers were synthesized in
one-pot azide–alkyne cycloaddition reactions with an adaptation of the Carothers equation …
[引用][C] Effects of Trehalose Polycation End-Group Functionalization on Plasmid DNA Uptake and Transfection
A Kevin, S Antons, C Mallory, W Chris, DM Haddleton - 2012
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