An experiment was conducted at Crop Research Station, Masodha (NDUAT), Dabhasemer, Faizabad, Uttar Pradesh to evaluate the bioefficacy of different herbicidal formulations viz. Butachlor (50 EC) @ 1500 g ai ha-1 at 5-7 DAT, Flucetosulfuron 10% WG @ 20 g ai ha-1 at 2-3 DAT, Flucetosulfuron 10% WG @ 25 g ai ha-1 at 2-3 DAT, Penoxsulam (1.02% W V-1) + Cyhalofop –butyl (5.1% W W-1) @120 g ai ha-1, Flucetosulfuron 10% WG + Bispyribac-sodium 10% SC @ 20 + 25 g ai ha-1 at 2-3 DAT followed by 15-20 DAT, Bispyribac-sodium 10% SC @ 25 g ai ha-1 at 4 - 6 leaf stage of weeds (15-20 DAT) against mechanical and need based hand weeding in sandy loam soil during kharif 2013 and 2014. The experimental findings shows that the major weed flora of transplanted rice during Kharif season included grasses Echinochloa colonum, Echinochloa crusgalli, Paspalum distichum sedges like Cyperus rotundus, Cyperus iria and broad leaf weeds Eclipta alba and Ammenia baccifera. Among different herbicidal formulatiuons Flucetosulfuron 10% WG + Bispyribac-sodium 10% SC @ 20 + 25 g ai ha-1 at 2-3 DAT followed by 15-20 DAT was most effective to control all types of weeds and check their growth in transplanted rice crop. This herbicidal combination also shows no phytotoxicity on rice crop. Therefore, Flucetosulfuron 10% WG + Bispyribac-sodium 10% SC @ 20+25 g ai ha-1 at 2-3 DAT followed by 15-20 DAT may be recommended to replace the tedious, time consuming and expensive hand weeding practices of weed control in transplanted Kharif rice.