Efficient Synthesis of 3-Bromo-2-[(N-substituted) amino] pyridines and their Hetarynic Cyclization
IC Grig-Alexa, AL Finaru, L Ivan, P Caubere… - …, 2006 - thieme-connect.com
IC Grig-Alexa, AL Finaru, L Ivan, P Caubere, G Guillaumet
Synthesis, 2006•thieme-connect.com… In the present paper we report the hetarynic synthesis of a large variety of N-substituted
dihydrodipyridopyrazines (DHDPP) by cyclization of the corresponding 3-bromo-2-[(N-substituted)amino]pyridines,
in the presence of the complex base (CB) NaNH 2 -tBuONa [3] (Scheme [1] ). … In
conclusion, we described a simple, convenient, and efficient protocol for the synthesis of
various 3-bromo-2-[(N-substituted)amino]pyridines used as precursors in the hetarynic
cyclization. We also reported the results of their arynic intermolecular cyclization. The …
dihydrodipyridopyrazines (DHDPP) by cyclization of the corresponding 3-bromo-2-[(N-substituted)amino]pyridines,
in the presence of the complex base (CB) NaNH 2 -tBuONa [3] (Scheme [1] ). … In
conclusion, we described a simple, convenient, and efficient protocol for the synthesis of
various 3-bromo-2-[(N-substituted)amino]pyridines used as precursors in the hetarynic
cyclization. We also reported the results of their arynic intermolecular cyclization. The …
Abstract
A variety of 3-bromo-2-[(N-substituted) amino] pyridines were obtained via two convenient methods and were used in the hetarynic synthesis of the corresponding N-substituted dihydrodipyridopyrazines.
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