The development of multidrug resistance in Gram-negative bacteria is a major problem
faced antimicrobial therapy and management of infectious diseases. Too many resistance
mechanisms were developed since the antimicrobial agents were produced and actually
used. The mechanisms involved in antimicrobial agents' resistance are, modifying enzymes,
alteration of the target site of antimicrobials and prevention of antimicrobials accumulation
inside the bacterial cells. The latest is accomplished by two mechanisms: alteration of outer …