Elafin is a biomarker of graft-versus-host disease of the skin

S Paczesny, TM Braun, JE Levine, J Hogan… - Science translational …, 2010 - science.org
… that elafin has significant diagnostic and prognostic value as a biomarker of skin GVHD. …
We evaluated elafin as a biomarker of skin GVHD in a validation set of 492 allogeneic BMT …

[HTML][HTML] Evaluation of elafin as a prognostic biomarker in acute graft-versus-host disease

MG Zewde, G Morales, I Gandhi, U Özbek… - … and cellular therapy, 2021 - Elsevier
… In contrast to the initial report of elafin as a biomarker of skin GVHD, the present study
found no difference in elafin concentration between clinical stages of skin disease and no …

Diagnostic and prognostic role of elafin in skin acute graft versus host disease: a systematic review

A Bhattarai, S Shah, R Yadav, G Dhakal, R Neupane… - …, 2024 - Taylor & Francis
Elafin has been recognized as a potential biomarker that differentiates … We set the search
strategy incorporating the search terms, ‘Elafin’, ‘graft versus host disease’, and ‘GVHD’, and …

Limited utility of plasma elafin as a biomarker for skin graftversushost disease following allogeneic stem cell transplantation

L George, G Mahabal, E Mohanan… - Clinical and …, 2021 - academic.oup.com
skin and absent in normal epidermis. Recently plasma elafin has been recognized as a
biomarker of skin GVHD (as shown by significantly higher levels at the onset of skin GVHD) and …

Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose …

L Solán, D Carbonell, P Muñiz, N Dorado… - Frontiers in …, 2021 - frontiersin.org
… Although the latter confirmed our results, the use of biomarkers in routine clinical practice …
fact that elafin is a valid plasma biomarker in the setting of haplo-HSCT with PTCy. Elafin could …

Utility of tissue elafin as an immunohistochemical marker for diagnosis of acute skin graftversushost disease: a pilot study

GD Mahabal, L George, D Peter… - Clinical and …, 2019 - academic.oup.com
… The skin is the most common organ involved in acute graftversushost disease (GvHD).
Because histopathology … Recently, elafin was identified as an important plasma biomarker for …

[HTML][HTML] Epidermal elafin expression is an indicator of poor prognosis in cutaneous graft-versus-host disease

MC Brüggen, P Petzelbauer, H Greinix… - Journal of Investigative …, 2015 - Elsevier
… We evaluated whether the analysis of elafin expression in skin would allow distinguishing
aGVHD … levels could be helpful diagnostic and predictive biomarkers in cutaneous aGVHD. …

[HTML][HTML] Elafin is a biomarker of graft versus host disease of the skin

S Paczesny, JE Levine, J Hogan, J Crawford, T Braun… - Blood, 2008 - Elsevier
… There are no plasma biomarkers that are specific to any … graft versus host disease (GVHD):
skin, GI tract and liver. We sought to identify a biomarker that is specific for GVHD of the skin

Discovery and validation of graft-versus-host disease biomarkers

S Paczesny - Blood, 2011 - Elsevier
… We showed that plasma elafin levels have significant diagnostic and prognostic power as
a biomarker of skin GVHD (2). Using the same proteomics strategy, we discovered …

Immunohistochemical markers for histopathological diagnosis and differentiation of acute cutaneous graftversushost disease

J Wegner, B Weidenthaler‐Barth… - Experimental …, 2021 - Wiley Online Library
elafin has been the only known biomarker of cutaneous GvHD used for both serum and skin
… In our study, elafin staining did not prove useful in distinguishing aGvHD from SJS/TEN and …