Background Heart failure is a final common pathway or descriptor for various cardiac
pathologies. It is associated with sudden cardiac death, which is frequently caused by
ventricular arrhythmias. Electrophysiological remodeling, intercellular uncoupling, fibrosis
and autonomic imbalance have been identified as major arrhythmogenic factors in heart
failure etiology and progression. Objective In this study we investigate in silico the role of
electrophysiological and structural heart failure remodeling on the modulation of key …

Background Heart failure is operationally defined as the inability of the heart to maintain
blood flow to meet the needs of the body and it is the final common pathway of various
cardiac pathologies. Electrophysiological remodeling, intercellular uncoupling and a pro-
fibrotic response have been identified as major arrhythmogenic factors in heart failure.
Objective In this study we investigate vulnerability to reentry under heart failure conditions by
incorporating established electrophysiological and anatomical remodeling using computer …