Electrostatic repulsion governs TDP-43 C-terminal domain aggregation
PLoS biology, 2016•journals.plos.org
TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In
response to a recent study, this Formal Comment argues that the pH-dependent solubility of
this protein is better explained by the mutual repulsion of charged groups than by the
formation of hydrogen bonds.
response to a recent study, this Formal Comment argues that the pH-dependent solubility of
this protein is better explained by the mutual repulsion of charged groups than by the
formation of hydrogen bonds.
TDP-43 is a protein that forms aggregates implicated in amyotrophic lateral sclerosis. In response to a recent study, this Formal Comment argues that the pH-dependent solubility of this protein is better explained by the mutual repulsion of charged groups than by the formation of hydrogen bonds.
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