Background—Apoptotic microparticles are responsible for almost all tissue factor activity of
the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles
could also circulate in the peripheral blood of patients with recent clinical signs of plaque
disruption and thrombosis. Methods and Results—We studied 39 patients with coronary
heart disease, including 12 patients with stable angina and 27 patients with acute coronary
syndromes (ACS), and 12 patients with noncoronary heart disease. We isolated the …

Materials and Methods: Consecutive patients admitted with SAH were prospectively
enrolled. Demographic (age, sex) and neurological (GSW, Hunt-Hess, WFNS and Fisher
scores) factors were recorded at admission. The Glasgow Outcome Scale (GOS) at 3 months
was evaluated. We isolated the circulating MP by capture with annexine V and determined
their procoagulant potential with a prothrombinase assay, at the day of the enrolment (D0)
and five days later (D5). The cellular origin of MP was determined by antigenic capture with …