Neurodegenerative tauopathies are hypothesized to propagate via brain networks. This is
uncertain because we have lacked precise network resolution of pathology. We therefore
developed whole-brain staining methods with anti-p-tau nanobodies and imaged in 3D
PS19 tauopathy mice, which have pan-neuronal expression of full-length human tau
containing the P301S mutation. We analyzed patterns of p-tau deposition across established
brain networks at multiple ages, testing the relationship between structural connectivity and …