Enhancement of cardiac store operated calcium entry (SOCE) within novel intercalated disk microdomains in arrhythmic disease

IM Bonilla, AE Belevych, S Baine, A Stepanov… - Scientific reports, 2019 - nature.com
… of SOCE proteins and functional events at the intercalated disk (ID), which electrically
and mechanically couples cardiac myocytes. Last but not least, our data suggest a novel

Role of store-operated Ca2+ entry in cardiovascular disease

T Lu, Y Zhang, Y Su, D Zhou, Q Xu - Cell Communication and Signaling, 2022 - Springer
… expression in the cardiovascular system of wild-type mice was enhanced, which was …
intercalated disk-residing proteins' functions. The role of SOCE in maintaining the intercalated disk

Store-operated calcium entry in the cardiovascular system

X Liu, Z Pan - Ion Channels in Biophysics and Physiology, 2022 - Springer
enhanced SOCE during cardiac hypertrophy and heartcalcium channels, possibly the Orais,
may be a novel cause of … found upregulated at the intercalated disk in CPVT and myocytes …

Store-Operated Calcium Entry Increases Nuclear Calcium in Adult Rat Atrial and Ventricular Cardiomyocytes

J Hermes, V Borisova, J Kockskämper - Cells, 2023 - mdpi.com
cardiac remodeling, but the underlying mechanisms remain elusive. We hypothesized
that SOCE may increase nuclear calcium… sarcolemma and at the intercalated disks [27,37,40,42]. …

Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells

A Uehara, M Yasukochi, I Imanaga, M Nishi… - Cell Calcium, 2002 - Elsevier
cardiac myocytes enhanced Ca2; entry when the stores were … located in the intercalated
discs between cardiac myocytes [25]. … Trp, a novel mammalian gene family essential for agonist-…

Role of Orai1 and Store Operated Calcium Entry (SOCE) in Liver: Effects on Hormone-Induced Calcium Signaling and Glucose Metabolism

GS Bird, D D'Agostin, P Desai, JW Putney - Biophysical Journal, 2019 - cell.com
… of L-type Ca2ū channels and enhanced activity of the Na ū /… periphery, particularly at
intercalated disks (IDs). These … cells (hiPSCs) provides a novel approach in human disease …

SOCE in the cardiomyocyte: the secret is in the chambers

P Rosenberg, H Zhang, VG Bryson, C Wang - Pflügers Archiv-European …, 2021 - Springer
… offer novel therapeutic targets for cardiac arrhythmias and the treatment of … store operated
Ca 2+ entry in adult cardiomyocytes. Any future therapeutic strategy designed around SOCE in …

Store-Operated Ca2+ Entry as a Putative Target of Flecainide for the Treatment of Arrhythmogenic Cardiomyopathy

F Moccia, V Brunetti, T Soda, P Faris… - Journal of Clinical …, 2023 - mdpi.com
… 2 translocates from the intercalated discs to the … entry in non-excitable cells [70,75,101],
revealed that SOCE was constitutively activated in C-hMSCs and was significantly enhanced

Super-resolution microscopy for the study of store-operated calcium entry

C Bastian, A Sampieri, MO Benavides, A Guerrero… - Cell Calcium, 2022 - Elsevier
… , resulting in enhanced activation of Orai currents and SOCE, … at discrete regions located
in the intercalated discs (IDs) [61]. … understanding SOCE dynamics we have learnt also novel

Targeting Orai1-Mediated Store-Operated Ca2+ Entry in Heart Failure

R Luo, AM Gomez, JP Benitah… - … in Cell and Developmental …, 2020 - frontiersin.org
… and impaired z-disc localization of calsarcin involved in the … of SOCE and/or conversely
the enhanced SOCE induced by … SOCE may be a novel therapeutic target to consider in heart