In the past decade, approximately 17 % of the world's photovoltaic capacity has been installed in China, especially in the northwestern desert areas. The impacts of the construction and operation of large-scale photovoltaic power plants (PPPs) on local ecological environments have become urgent scientific issues in regional environmental protection decision-making. To quantitatively evaluate the local environmental impacts of the construction and operation of PPPs in the desert oasis region, thermal infrared and multispectral sensors mounted on unmanned aerial vehicles (UAVs) as well as X-ray fluorescence spectrometers and soil sensors were used in this study to monitor a large PPP in Northwest China. We found that the construction and operation of PPPs can promote biological soil crust development and vegetation growth and can thus improve the soil texture and nutrition. However, the Ca, S and Cl concentrations were found to be 3, 5 and 1.7 times higher inside the PPP area than outside the PPP area, respectively. In addition, the soil salinization is also more severe inside the PPP area. In future studies, it is essential to further elucidate the impacts of PPP operations and agricultural on desert ecosystems.