Enzyme-linked immunosorbent assay for the diagnosis of melioidosis: better than we thought
D Limmathurotsakul, N Chantratita… - Clinical infectious …, 2011 - academic.oup.com
Clinical infectious diseases, 2011•academic.oup.com
We used Bayesian latent-class models to generate receiver operating characteristic curves
and to revise the cutoff values for an enzyme-linked immosorbent assay that has been
developed previously for melioidosis. The new cutoff was unbiased towards
misclassification caused by an imperfect gold standard and resulted in an increase in both
sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).
and to revise the cutoff values for an enzyme-linked immosorbent assay that has been
developed previously for melioidosis. The new cutoff was unbiased towards
misclassification caused by an imperfect gold standard and resulted in an increase in both
sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).
Abstract
We used Bayesian latent-class models to generate receiver operating characteristic curves and to revise the cutoff values for an enzyme-linked immosorbent assay that has been developed previously for melioidosis. The new cutoff was unbiased towards misclassification caused by an imperfect gold standard and resulted in an increase in both sensitivity (from 66.4% to 80.2%) and specificity (82.1% and 95.0%).
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