Background Pediatric arterial ischemic stroke remains incompletely understood. Population-
based epidemiological data inform clinical trial design but are scant in this condition. We
aimed to determine age-specific epidemiological characteristics of arterial ischemic stroke in
neonates (birth to 28 days) and older children (29 days to 18 years). Methods We conducted
a 16-year, prospective, national population-based study, the Canadian Pediatric Ischemic
Stroke Registry, across all 16 Canadian acute care children's hospitals. We prospectively …