Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets

F Lizcano, J Garcia - Pharmaceuticals, 2012 - mdpi.com
The development of cancer involves an immense number of factors at the molecular level.
These factors are associated principally with alterations in the epigenetic mechanisms that
regulate gene expression profiles. Studying the effects of chromatin structure alterations,
which are caused by the addition/removal of functional groups to specific histone residues,
are of great interest as a promising way to identify markers for cancer diagnosis, classify the
disease and determine its prognosis, and these markers could be potential targets for the …

Epigenetic control and cancer: the potential of histone demethylases as therapeutic targets

F Lizcano Losada, J García Serrano - intellectum.unisabana.edu.co
The development of cancer involves an immense number of factors at the molecular level.
These factors are associated principally with alterations in the epigenetic mechanisms that
regulate gene expression profiles. Studying the effects of chromatin structure alterations,
which are caused by the addition/removal of functional groups to specific histone residues,
are of great interest as a promising way to identify markers for cancer diagnosis, classify the
disease and determine its prognosis, and these markers could be potential targets for the …
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