Epigenetic control of gene expression is critical for normal fetal development. However,
chromatin-related mechanisms that activate bone-specific programs during osteogenesis
have remained underexplored. Therefore, we investigated the expression profiles of a large
cohort of epigenetic regulators (> 300) during osteogenic differentiation of human
mesenchymal cells derived from the stromal vascular fraction of adipose tissue (AMSCs).
Molecular analyses establish that the polycomb group protein EZH2 (enhancer of zeste …