… epigenetic-based drugs are undergoing clinical trials. Here, we describe the timeline of
epigenetic drug discovery … -of-the-art rational epigenetic drug discovery using validated targets. …

… advances in computational approaches to epigenetic drug discovery and summarize, to the
best of our knowledge, all the publicly available chemogenomics data for epigenetic targets. …

… restoring of epigenetic aberrations, unlike genetic mutations, sited epigenetic-based therapy
… This chapter reviews the main potential epigenetic-based compounds that have been used …

… in drug discovery. Areas covered: This article focuses on the concepts and drug discovery
aspects … concepts: (i) factors influencing epigenetics, (ii) diseases arising from epigenetics, (iii) …

… epigenetics in guiding cell fate decisions during immune responses and have also highlighted
the potential for targeting epigenetic … advanced areas of epigenetic drug development for …

… as challenges to epigenetic drug discovery with emerging biology and novel classes of
drug targets. We will also highlight recent successes in cancer epigenetics drug discovery and …

… epigenetic targets emerges, 181 the opportunities for testing combinations of epigenetic
drugs … Epigenetic drug development will continue to enhance the armamentarium of therapies …

… Epigenetic regulation of gene expression is a dynamic and … At the molecular level,
epigenetic regulation involves … Here, we review the key protein families that mediate epigenetic …

… epigenetically reprogrammed to a healthy one. For convenience, epigenetic targets for drug
discovery … erasers' have reached different stages of the drug discovery process (table 1). At …

… drugs for these indications. It is our opinion that the currently approved epigenetic drugs are
… Strong target validation exists for important roles of other classes of epigenetic enzymes in …