Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma
Epithelial-Mesenchymal Transition (EMT) is a critical step in the progression of cancer.
Malignant melanoma, a cancer developed from pigmented melanocytes, metastasizes
through an EMT-like process. Ten-eleven translocation (TET) enzymes, catalyzing the
conversion of 5-methylcytosine (5mC) to 5-hydroxylmethylcytosine (5-hmC), are down
regulated in melanoma. However, their roles in the progression and the EMT-like process of
melanoma are not fully understood. Here we report that DNA methylation induced silencing …
Malignant melanoma, a cancer developed from pigmented melanocytes, metastasizes
through an EMT-like process. Ten-eleven translocation (TET) enzymes, catalyzing the
conversion of 5-methylcytosine (5mC) to 5-hydroxylmethylcytosine (5-hmC), are down
regulated in melanoma. However, their roles in the progression and the EMT-like process of
melanoma are not fully understood. Here we report that DNA methylation induced silencing …
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