Sensory inputs activate sparse neuronal ensembles in the dentate gyrus of the
hippocampus, but how eligibility of individual neurons to recruitment is determined remains
elusive. We identify thousands of largely bistable (CpG methylated or unmethylated) regions
within neuronal gene bodies, established during mouse dentate gyrus development.
Reducing DNA methylation and the proportion of the methylated epialleles at bistable
regions compromises novel context-induced neuronal activation. Conversely, increasing …

Episodic memories are stored in distributed neurons but how eligibility of individual neurons
to coding ensembles is determined remains elusive. We identified thousands of
predominantly bistable (CpG methylated or unmethylated) regions within neuronal gene
bodies, established during the development of the mouse hippocampal dentate gyrus.
Reducing DNA methylation and the proportion of the methylated epialleles at bistable
regions compromised novel context-induced neuronal activation and spatial memory …