Epileptic seizures are preceded by a decrease in synchronization

F Mormann, T Kreuz, RG Andrzejak, P David… - Epilepsy research, 2003 - Elsevier
The exact mechanisms leading to the occurrence of epileptic seizures in humans are still
poorly understood. It is widely accepted, however, that the process of seizure generation is
closely associated with an abnormal synchronization of neurons. In order to investigate this
process, we here measure phase synchronization between different regions of the brain
using intracranial EEG recordings. Based on our preliminary finding of a preictal drop in
synchronization, we investigate whether this phenomenon can be used as a sensitive and …
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