Collective motions of groups of cells are observed in many biological settings such as
embryo development, tissue formation, and cancer metastasis. To effectively model
collective cell movement, it is important to incorporate cell specific features such as cell size,
cell shape, and cell mechanics, as well as active behavior of cells such as protrusion and
force generation, contractile forces, and active biochemical signaling mechanisms that
regulate cell behavior. In this paper, we develop a comprehensive model of collective cell …