Estimating temporally variable selection intensity from ancient DNA data

Z He, X Dai, W Lyu, M Beaumont… - Molecular Biology and …, 2023 - academic.oup.com
… To address these challenges, in this work, we introduce a novel Bayesian approach for
estimating temporally variable selection intensity from aDNA data whereas modeling sample …

Estimating temporally variable selection intensity from ancient DNA data with the flexibility of modelling linkage and epistasis

Z He, X Dai, W Lyu, M Beaumont… - Molecular Ecology …, 2023 - Wiley Online Library
selection … of genetic interactions in the inference of selection. To address this issue, we
extend the approach of He et al., 2023 to infer temporally variable selection from the aDNA data

Estimating temporally variable selection intensity from ancient DNA data II

W Lyu, X Dai, M Beaumont, F Yu, Z He - bioRxiv, 2023 - biorxiv.org
… Here we introduce a novel Metropolis-Hastings (MH) within Gibbs framework for estimating
temporally variable selection intensities from the aDNA data in the form of genotype …

Using phylochronology to reveal cryptic population histories: review and synthesis of 29 ancient DNA studies

UMA Ramakrishnan, EA Hadly - Molecular ecology, 2009 - Wiley Online Library
selection intensities Standardizing with mitochondrial DNA … of ancient genetic studies
focused on the temporal analysis of … We are interested in estimating the species effective …

The contribution of gene flow, selection, and genetic drift to five thousand years of human allele frequency change

A Simon, G Coop - Proceedings of the National Academy of …, 2024 - National Acad Sciences
… Thus our simulations suggest that while temporal binning of ancient DNA samples … calculate
the sampling biases in the specific case of pseudohaploid data in line with the ancient DNA

The genome-wide signature of short-term temporal selection

M Lynch, W Wei, Z Ye, M Pfrender - … of the National Academy of Sciences, 2024 - pnas.org
genetic isolates of a population of the microcrustacean Daphnia pulex demonstrates that
temporal variation in selection intensity … to estimate with high accuracy the selection coefficient s …

Estimation of 2Nes From Temporal Allele Frequency Data

JP Bollback, TL York, R Nielsen - Genetics, 2008 - academic.oup.com
estimate selection coefficients acting on the CCR5-Δ32 mutation on the basis of published
samples of contemporary and ancient human DNA… related to the strength of selection. The …

Dairying, diseases and the evolution of lactase persistence in Europe

RP Evershed, G Davey Smith, M Roffet-Salque… - Nature, 2022 - nature.com
… but varied spatially and temporally in intensity. Notably, LP selection varying with levels of
Ancient DNA (aDNA) data indicate that most, if not all, Early Neolithic people were lactase …

Direct evidence for positive selection of skin, hair, and eye pigmentation in Europeans during the last 5,000 y

S Wilde, A Timpson, K Kirsanow… - Proceedings of the …, 2014 - National Acad Sciences
… have poor sensitivity and temporal resolution, most are … the strength of the selection coefficients
in a certain time window can be estimated with improved precision using our ancient DNA

Fluctuating selection and the determinants of genetic variation

OL Johnson, R Tobler, JM Schmidt, CD Huber - Trends in Genetics, 2023 - cell.com
… frequencies, bringing temporally fluctuating selection to the … of neutrality is the strength
of selection acting on a variant … Estimates of loci under selection have generally been small …