Background Lung cancer screening with low-dose computed tomography (LDCT) reduces
lung cancer mortality. The aim of this study was to evaluate the cost-effectiveness of lung
cancer screening with LDCT in a high-risk population. Methods The study used an adapted
microsimulation model in a cohort of Dutch heavy smokers for a lifetime horizon from a
health insurance perspective. The main outcomes included average cost-effectiveness ratio
(ACER), incremental cost-effectiveness ratio (ICER) and lung cancer mortality reduction. The …

Introduction Health economic evaluations of lung cancer screening with low-dose computed
tomography (LDCT) that are underpinned by clinical outcomes are relatively few. Methods
We assessed the cost-effectiveness of LDCT lung screening in Australia by applying
Australian cost and survival data to the outcomes observed in the US National Lung
Screening Trial (NLST), in which a 20% lung cancer mortality benefit was demonstrated for
three rounds of annual screening among high-risk smokers age 55 to 74 years. Screening …