[HTML][HTML] Eudragit S100 coated citrus pectin nanoparticles for colon targeting of 5-fluorouracil
In the present study, Eudragit S100 coated Citrus Pectin Nanoparticles (E-CPNs) were
prepared for the colon targeting of 5-Fluorouracil (5-FU). Citrus pectin also acts as a ligand
for galectin-3 receptors that are over expressed on colorectal cancer cells. Nanoparticles
(CPNs and E-CPNs) were characterized for various physical parameters such as particle
size, size distribution, and shape etc. In vitro drug release studies revealed selective drug
release in the colonic region in the case of E-CPNs of more than 70% after 24 h. In vitro …
prepared for the colon targeting of 5-Fluorouracil (5-FU). Citrus pectin also acts as a ligand
for galectin-3 receptors that are over expressed on colorectal cancer cells. Nanoparticles
(CPNs and E-CPNs) were characterized for various physical parameters such as particle
size, size distribution, and shape etc. In vitro drug release studies revealed selective drug
release in the colonic region in the case of E-CPNs of more than 70% after 24 h. In vitro …
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