[PDF][PDF] Evaluating the cytotoxic potential of methonolic leaf extract of Aloe vera on MCF-7 breast cancer cell lines
R Srihari, AR Surendranath… - … Journal of Pharmacy …, 2015 - researchgate.net
R Srihari, AR Surendranath, N Kasturacharya, KC Shivappa, ND Sivasitambaram…
International Journal of Pharmacy Pharmaceutical Sciences, 2015•researchgate.netObjective: Breast cancer is the second leading cause of death among cancer pateints.
Ayurvedic system of traditional medicine validated the use of plants as a useful source for
occurrence of anticancer compounds. This study was attempted to investigate the in vitro
anti-cancer potential of methanolic extract of Aleo vera on breast cancer MCF-7 cell lines.
Methods: The methanol extract of Aleo vera was screened for its anti-proliferative effect
against MCF-7 (Breast cancer) cell lines seeded on 96 well plates. Results: MCF-7 cells …
Ayurvedic system of traditional medicine validated the use of plants as a useful source for
occurrence of anticancer compounds. This study was attempted to investigate the in vitro
anti-cancer potential of methanolic extract of Aleo vera on breast cancer MCF-7 cell lines.
Methods: The methanol extract of Aleo vera was screened for its anti-proliferative effect
against MCF-7 (Breast cancer) cell lines seeded on 96 well plates. Results: MCF-7 cells …
Abstract
Objective: Breast cancer is the second leading cause of death among cancer pateints. Ayurvedic system of traditional medicine validated the use of plants as a useful source for occurrence of anticancer compounds. This study was attempted to investigate the in vitro anti-cancer potential of methanolic extract of Aleo vera on breast cancer MCF-7 cell lines.
Methods: The methanol extract of Aleo vera was screened for its anti-proliferative effect against MCF-7 (Breast cancer) cell lines seeded on 96 well plates.
Results: MCF-7 cells were treated with the extract for 24h and 72h at a range of increasing concentrations (0-500μg/ml) in order to obtain a doseresponse graph and IC50 value. The Aleo vera extract showed cytotoxic effect in MCF-7cells with IC50 of 74.33 μg/ml.
Conclusion: The Aleo vera extract showed effective cytotoxic activity in a dose and time dependent manner. Future investigations will be interesting to find an active principle and also better understand its mechanism of action against cancer.
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