Evaluation of first-line anticonvulsants to treat nerve agent-induced seizures and prevent neuropathology in adult and pediatric rats
Risk exists for civilian exposure to nerve agents (NA), and exposure can produce prolonged
seizures. Pediatric populations are at greater risk for injury or death due to the central
nervous system effects of NAs. To address the need to evaluate the effectiveness of
anticonvulsants, pediatric and adult animal models were established to test the effectiveness
of anticonvulsant drugs for treating NA-induced seizures in pediatric populations. In this
paper, median effective dose (ED50) and neuroprotective effectiveness were determined for …
seizures. Pediatric populations are at greater risk for injury or death due to the central
nervous system effects of NAs. To address the need to evaluate the effectiveness of
anticonvulsants, pediatric and adult animal models were established to test the effectiveness
of anticonvulsant drugs for treating NA-induced seizures in pediatric populations. In this
paper, median effective dose (ED50) and neuroprotective effectiveness were determined for …
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