The antiplasmodial activity of ethanol leaf extract of Aspilia africana was evaluated in mice infected with Plasmodium berghei berghei during early and established infections. A. africana extract (100-300 mg/kg/day) exhibited a significant (p<0.05) blood schizonticidal activity both in 4 day early infection and in established infection. The extract produced a significant (p<0.05) chemosuppression in both early and established infections tests though lower than that produced by chloroquine, 5 mg/kg/day. Also, significant mean survival time was recorded in extract treated groups compared to the control group during established infection. The leaf extract possesses a promising antiplasmodial activity which can be exploited in malaria therapy.